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However, the team’s study only looked at a very small number of people, so strong conclusions cannot be drawn yet.
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“Given that the protein is known to be important in synapse formation, you can see how maternal antibodies might affect the wiring of the fetal brain, and that might explain why each subsequent son is more likely to grow up gay.” “This is a very important study because it provides a plausible mechanism to explain the fraternal birth order effect, perhaps the most firmly established phenomenon related to human sexual orientation,” says Marc Breedlove at Michigan State University. “The mother’s immune response may alter the typical function of these brain structures.” “So it could affect brain structures that moderate attraction,” he says. The protein targeted by the antibodies, called NLGN4Y, is thought to play a role in how brain cells connect to each other, says Bogaert. They thought this would be a good candidate, because it plays an important role in how neurons communicate with each other, and because it is produced on the surface of brain cells, making it relatively easy for antibodies to find and detect it. The team collected blood from 142 women, and screened it for antibodies to a particular brain protein that is only made in males. Bogaert’s team wondered if maternal antibodies might play a role in shaping sexual orientation. But pregnant women sometimes also produce antibodies against fetal molecules – for example, if their fetus has a different blood group. Our immune systems make antibodies to recognise foreign molecules, which have the potential to be from dangerous bacteria. Now it seems that increasing levels of antibodies in a mother’s immune system could play a role.Īnthony Bogaert at Brock University, Canada, and his team think that some women who are pregnant with boys develop antibodies that target a protein made by the Y chromosome. The more older brothers a boy has, the more likely he is to be gay when he grows up – an effect called the “ fraternal birth order effect”. Oil on canvas.Having lots of boys can affect a woman’s immune response Walter Gay (1856–1937), Interior of the Artist's Apartment, undated. Across Photoarchive files, researchers can make their own connections among themes of portraiture and emptiness, and artists like Water Gay, Joseph Ducreux, and Goya and his followers. In Interior of the Artist’s Apartment, Ducreux stands in as the identifiable face to Walter Gay’s living room, and the directness of Ducreux’s portrait remains central to both pictures. Working in his own home, Gay sometimes included images of himself and Matilda, adding a more literal expression of portraiture to his work. Half-closed doors, wrinkled sheets, and cluttered arrangements of bibelots speak as much to the unseen occupants as they do to those qualities innate to a space itself. The portrait also complemented Walter Gay’s interior scenes, in which he imbues rooms with moods and personalities. It is also possible that the Goya-esque quality observed in 1949 references Matilda Gay’s appreciation of the Spanish temperament: in a diary entry, she describes an acquaintance who “looks just like a Goya, and has the fougueux quality of a man of that epoch.” The picture presumably appealed to the Gays’ love of eighteenth-century French art. It is not known when the Gays might have acquired this version of Ducreux’s painting, of which several replicas and copies are known to exist. Its twenty-first-century fame is due largely to a 2009 internet meme called “Archaic Rap,” in which images of Ducreux’s paintings captioned with slangy one-liners and Britishisms were widely tweeted and shared on Facebook. When Interior of the Artist’s Apartment was exhibited at the Wadsworth Athenaeum, Hartford, in 1949, five years before it was accessioned by the Pennsylvania Academy of the Fine Arts, the portrait was listed as “probably by Goya or one of his followers.” Today, it is recognized as a self-portrait by the French painter Joseph Ducreux (1735–1802). The portrait hangs above a bright blue settee and is surrounded by a cluster of five small landscapes. Prominently featured in this corner of the room is a large portrait of a man, grinning and pointing at the viewer. Interior of the Artist’s Apartment, made sometime after 1910 by the American painter and watercolorist Walter Gay, shows a narrow view of a sitting area in Walter and his wife Matilda’s Paris apartment at 11 Rue de l'Université, where the couple had moved in May 1909.